Biography
Kratz worked as research fellow in the Thoracic Oncology Lab from 2008-2011 where he played a pivotal role in the development of a prognostic assay for early-stage lung cancer patients. The novel assay was validated in an international clinical trial led by thoracic surgeons David M. Jablons, M.D. and Michael Mann, M.D. The assay better predicted risk of death in early-stage lung cancer patients versus conventional staging guidelines and later successfully identified Stage 1A lung cancer patients who had a very high likelihood of mortality after surgery. Kratz finished his clinical training as a clinical fellow in Thoracic Surgery at UCSF from 2014 - 2017 and subsequently joined the faculty.
Kratz holds the Van Auken Endowed Chair in Thoracic Oncology. He has been the recipient of numerous awards and honors including the UCSF Health Exceptional Physician Award, Hellman Family Clinical-Translational Research Development Award, Michael DeBakey Research Scholarship, Cardiothoracic Surgery Faculty Teaching Award, Haile T. Debas Academy of Medical Educators Excellence in Teaching Award, Partners Healthcare Teaching Award, Willard M. Daggett Award, Edward Churchill Surgical Research Fellowship, Wyeth Scholarship of the American College of Surgeons, John E. Thayer Scholarship Award, Howard Hughes Medical Fellows Program Continued Support Award, and designation as a Soma Weiss Scholar.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California | Fellowship | Cardiothoracic Surgery | 2017 |
Massachusetts General Hospital | Residency | General Surgery | 2014 |
Harvard Medical School | M.D. (Magna Cum Laude) | 2006 | |
Stanford University | M.A. | Philosophy | 2000 |
Stanford University | B.S. (with Honors with Distinction) | Biological Sciences | 1999 |
Stanford University | B.A. (with Distinction) | Philosophy | 1999 |
Board Certifications
American Board of Surgery
American Board of Thoracic Surgery
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Haile T. Debas Academy of Medical Educators Excellence in Teaching Award | University of California, San Francisco | 2023 |
Cardiothoracic Surgery Faculty Teaching Award | University of California, San Francisco | 2021 |
Michael DeBakey Research Scholarship | American Association for Thoracic Surgery | 2019 |
Hellman Family Clinical-Translational Research Development Award | Bakar ImmunoX Initiative | 2019 |
Haile T. Debas Academy of Medical Educators Excellence in Teaching Award | University of California, San Francisco | 2019 |
Van Auken Endowed Chair in Thoracic Oncology | University of California, San Francisco | 2018 |
UCSF Health Exceptional Physician Award | University of California, San Francisco | 2017 |
First Place, Oral Presentation, Harvard Medical School Surgery Research Conference | Harvard Medical School | 2012 |
Partners HealthCare Resident/Fellow as Teacher Award | Partners HealthCare | 2012 |
President's Conference Selection, World Conference on Lung Cancer | International Association for the Study of Lung Cancer | 2011 |
Willard M. Daggett Award | Massachusetts General Hospital | 2010 |
Wyeth Scholarship of the American College of Surgeons for the Study of Inflammation | Massachusetts General Hospital | 2008 |
Aesculapian Club | Harvard Medical School | 2006 |
John E. Thayer Scholarship Award | Harvard Medical School | 2006 |
Soma Weiss Scholar Award | Harvard Medical School | 2005 |
Howard Hughes Research Training Fellowship | Harvard Medical School | 2004 |
Clinical Expertise
Carcinoid Tumors
Chest Wall Tumors
Lung Transplantation
Malignant Mesothelioma
Mediastinal Masses
Minimally Invasive Thoracic Surgery
Non-Small Cell Lung Cancer
Robotic Thoracic Surgery
Small Cell Lung Cancer
Thymoma & Thymic Carcinoma
Tracheal Tumors
Video-Assisted Thoracoscopic Surgery (VATS)
Clinical Trials
- Related Conditions: Postoperative Pain, Opioid Use| Start Date: | End Date:
In the News
Grants and Funding
- Immune Phenotypes of High-Risk Early Stage Lung Adenocarcinoma | American Association of Thoracic Surgery | 2020-07-01 - 2022-06-30 | Role: Principal Investigator
- CoProject Pilot in Early-Stage Lung Cancer | Bakar ImmunoX Foundation | 2019-08-01 - 2021-07-31 | Role: Principal Investigator
- COVID-19 Related Rapid Research Pilot Initiative | University of California, San Francisco | 2020-06-03 - 2021-06-02 | Role: Principal Investigator
- Lung Cancer Tumor Immune Microenvironments | Helen Diller Family Comprehensive Cancer Center | 2019-10-19 - 2020-09-30 | Role: Principal Investigator
Research Narrative
The Kratz lab focuses on the genetic and immunological mechanisms that drive early-stage, surgically resectable thoracic malignancies. These malignancies include lung cancer, esophageal cancer, and thymic cancer. The lab uses novel high-throughput “-omics” techniques such as genomic DNA and RNA sequencing, proteomics, and metabolomics to unravel the complex nature of early-stage thoracic malignancies. At the same time, the lab actively investigates the complex immunological landscapes that nurture the growth of these malignancies. The knowledge gained from these investigations is being used to identify novel therapeutic targets and therapies for patients with early-stage, yet deadly thoracic malignancies.
Research Interests
Molecularly-targeted cancer therapies
Prognostic assays for early stage lung cancer
Inflammation in lung tumorigenesis
Publications
- The race to liver transplantation: a comparison of patients with and without hepatocellular carcinoma from listing to post-transplantation.| | PubMed
- Prognostic and Predictive Biomarker Signatures.| | UCSF Research Profile
- The migrated liver transplantation candidate: insight into geographic disparities in liver distribution.| | PubMed
- Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.| | PubMed
- International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature.| | PubMed
- Prognostic assay in small, node-negative non-small cell lung cancer--reply.| | PubMed
- The role of stem cells in airway repair: implications for the origins of lung cancer.| | PubMed
- A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors.| | PubMed
- Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.| | PubMed
- A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.| | PubMed